The Case of a Missing HLA-B Gene.

doi:10.1111/tan.70114

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Article

The Case of a Missing HLA-B Gene.

HLA - 1 Mar 2025

Cline Noah, Merlo Dario, Frater Sandra, Pollock Nicholas R, Mayor Neema P, Turner Thomas R, Walsh Lisa, Vivers Sharon, Norman Paul J

Abstract excerpt

The Major Histocompatibility Complex (MHC) of human chromosome 6 contains multiple genes critical for immunity. The exceptional polymorphism of this genomic region that establishes and maintains immune diversity can be technically challenging to characterise and analyse. In this study, we present a family where the mother and one of her children have no HLA-B allele in common, implying the absence of HLA-B from...

Topics

Humans
Female
Haplotypes
Alleles
HLA-B Antigens
Chromosomes, Human, Pair 6
Homozygote
Male
High-Throughput Nucleotide Sequencing
Sequence Deletion
Pedigree
Sequence Analysis, DNA

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Identifiers

PMID: 40117098
DOI: 10.1111/tan.70114
PMCID: PMC11932453

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