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Article

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.

American journal of human genetics - 4 Aug 2016

Norman Paul J, Hollenbach Jill A, Nemat-Gorgani Neda, Marin Wesley M, Norberg Steven J, Ashouri Elham, Jayaraman Jyothi, Wroblewski Emily E, Trowsdale John, Rajalingam Raja, Oksenberg Jorge R, Chiaroni Jacques, Guethlein Lisbeth A, Traherne James A, Ronaghi Mostafa, Parham Peter

Abstract excerpt

The physiological functions of natural killer (NK) cells in human immunity and reproduction depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIRs) and their HLA class I ligands: HLA-A, HLA-B, and HLA-C. The genomic regions containing the KIR and HLA class I genes are unlinked, structurally complex, and highly polymorphic. They are also strongly associated with a wide spectrum of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27486779
DOI: 10.1016/j.ajhg.2016.06.023
PMCID: PMC4974113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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