Article
Interrogating the major histocompatibility complex with high-throughput genomics.
Human molecular genetics - 15 Oct 2012
de Bakker Paul I W, Raychaudhuri Soumya
Abstract excerpt
The major histocompatibility complex (MHC) region on the short arm of chromosome 6 harbors the largest number of replicated associations across the human genome for a wide range of diseases, but the functional basis for these associations is still poorly understood. One fundamental challenge in fine-mapping associations to functional alleles is the enormous sequence diversity and broad linkage disequilibrium of...
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