Article
Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies.
American journal of human genetics - 6 Aug 2015
Kichaev Gleb, Pasaniuc Bogdan
Abstract excerpt
Localization of causal variants underlying known risk loci is one of the main research challenges following genome-wide association studies. Risk loci are typically dissected through fine-mapping experiments in trans-ethnic cohorts for leveraging the variability in the local genetic structure across populations. More recent works have shown that genomic functional annotations (i.e., localization of...
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