Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methods for statistical fine-mapping and their applications to auto-immune diseases.

Seminars in immunopathology - 1 Jan 2022

Wang Qingbo S, Huang Hailiang

Abstract excerpt

Although genome-wide association studies (GWAS) have identified thousands of loci in the human genome that are associated with different traits, understanding the biological mechanisms underlying the association signals identified in GWAS remains challenging. Statistical fine-mapping is a method aiming to refine GWAS signals by evaluating which variant(s) are truly causal to the phenotype. Here, we review the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome-Wide Association Study
Share to Immune System Diseases
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 35041074
DOI: 10.1007/s00281-021-00902-8
PMCID: PMC8837575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methods for statistical fine-mapping and their applications to auto-immune diseases.PMID 35041074Read ↗

A catalog of GWAS fine-mapping efforts in autoimmune diseaseSemantic proximity Read ↗

From genome-wide associations to candidate causal variants by statistical fine-mapping.Semantic proximity Read ↗

Strategies for fine-mapping complex traits.Semantic proximity Read ↗

Genetic and epigenetic fine mapping of causal autoimmune disease variants.Semantic proximity Read ↗

ANNORE: genetic fine-mapping with functional annotation.Semantic proximity Read ↗

Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies.Semantic proximity Read ↗

Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseasesSemantic proximity Read ↗

Sharing information between related diseases using Bayesian joint fine mapping increases accuracy and identifies novel associations in six immune mediated diseasesSemantic proximity Read ↗

Fine-mapping genetic associations.Semantic proximity Read ↗

A Unifying Statistical Framework to Discover Disease Genes from GWASSemantic proximity Read ↗

Genome-wide fine-mapping improves identification of causal variants.Semantic proximity Read ↗

[Fine mapping of complex disease susceptibility loci].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.