Article

Genome-wide fine-mapping improves identification of causal variants

2024-07-19

Abstract excerpt

Fine-mapping refines genotype-phenotype association signals to identify causal variants underlying complex traits. However, current methods typically focus on individual genomic loci and do not account for the global genetic architecture. Here, we demonstrate the advantages of performing genome-wide fine-mapping (GWFM) with functional annotations and develop methods to facilitate GWFM. In simulations and real data...

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Literature Corpus work: 9db23d18-c38a-583d-96a7-a42d75220565
DOI: 10.1101/2024.07.18.24310667

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