Article
Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci.
PLoS genetics - 1 Jan 2015
van de Bunt Martijn, Cortes Adrian, Brown Matthew A, Morris Andrew P, McCarthy Mark I
Abstract excerpt
The growing availability of high-quality genomic annotation has increased the potential for mechanistic insights when the specific variants driving common genome-wide association signals are accurately localized. A range of fine-mapping strategies have been advocated, and specific successes reported, but the overall performance of such approaches, in the face of the extensive linkage disequilibrium that...
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