ANNORE: genetic fine-mapping with functional annotation.

doi:10.1093/hmg/ddab210

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

ANNORE: genetic fine-mapping with functional annotation.

Human molecular genetics - 17 Dec 2021

Fisher Virginia, Sebastiani Paola, Cupples L Adrienne, Liu Ching-Ti

Abstract excerpt

Genome-wide association studies (GWASs) have successfully identified loci of the human genome implicated in numerous complex traits. However, the limitations of this study design make it difficult to identify specific causal variants or biological mechanisms of association. We propose a novel method, AnnoRE, which uses GWAS summary statistics, local correlation structure among genotypes and functional annotation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Genome-Wide Association Study
Share to Multifactorial Inheritance
Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 34302344
DOI: 10.1093/hmg/ddab210
PMCID: PMC8682766

Provenance

PubMed metadata and Literature Corpus relationships.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Quantitative Trait Loci