Article
Genome-wide fine-mapping improves identification of causal variants.
Nature genetics - 1 Apr 2026
Wu Yang, Zheng Zhili, Thibaut Loic, Lin Tian, Feng Qian, Cheng Hao, Yengo Loic, Goddard Michael E, Wray Naomi R, Visscher Peter M, Zeng Jian
Abstract excerpt
Fine-mapping refines genotype-phenotype association signals to identify causal variants underlying complex traits. However, current methods typically focus on individual genomic loci and do not account for the global genetic architecture. Here we demonstrate the advantages of performing genome-wide fine-mapping (GWFM) with functional annotations and develop methods to facilitate GWFM. In simulations and real data...
Topics
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide
- Humans
- Chromosome Mapping
- Schizophrenia
- Phenotype
- Genetic Predisposition to Disease
- Quantitative Trait Loci
- Crohn Disease
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO