Article
Identifying candidate causal variants via trans-population fine-mapping.
Genetic epidemiology - 1 Nov 2010
Teo Yik-Ying, Ong Rick T H, Sim Xueling, Tai E-Shyong, Chia Kee-Seng
Abstract excerpt
Genome-wide association studies have discovered and confirmed a large number of loci that are implicated with disease susceptibility and severity. Polymorphisms that emerged from these studies are mostly indirectly associated to the phenotype, and the natural progression is to identify the causal variants that are functionally responsible for these association signals. Long stretches of high linkage...
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