Funmap: integrating high-dimensional functional annotations to improve fine-mapping.

Abstract excerpt

MOTIVATION: Fine-mapping aims to prioritize causal variants underlying complex traits by accounting for the linkage disequilibrium of genome-wide association study risk locus. The expanding resources of functional annotations serve as auxiliary evidence to improve the power of fine-mapping. However, existing fine-mapping methods tend to generate many false positive results when integrating a large number of...

Topics

• Genome-Wide Association Study
• Polymorphism, Single Nucleotide
• Chromosome Mapping
• Algorithms
• Software
• Humans