Article
Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer.
International journal of oncology - 1 Sept 2015
Uzawa Katsuhiro, Kasamatsu Atsushi, Baba Takao, Kimura Yasushi, Nakashima Dai, Higo Morihiro, Sakamoto Yosuke, Ogawara Katsunori, Shiiba Masashi, Tanzawa Hideki
Abstract excerpt
Circulating tumor cells (CTCs) and/or their relating molecules are promising determinants during the course of cancer treatment, especially for post-therapeutic monitoring. We recently reported the clinical relevance of detecting circulating tumor-associated mutant mitochondrial DNAs (mut-mtDNAs) at three different regions including the displacement loop, 12S-rRNA and 16S-rRNA in oral squamous cell carcinomas...
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