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Article

Clinical significance in oral cavity squamous cell carcinoma of pathogenic somatic mitochondrial mutations.

PloS one - 1 Jan 2013

Lai Chih-Hsiung, Huang Shiang-Fu, Liao Chun-Ta, Chen I-How, Wang Hung-Ming, Hsieh Ling-Ling

Abstract excerpt

Somatic mutations affecting the mitochondrial DNA (mtDNA) have been frequently observed in human cancers and proposed as important oncological biomarkers. However, the clinical significance of mtDNA mutations in cancer remains unclear. This study was therefore performed to explore the possible clinical use in assessing oral squamous cell carcinoma (OSCC) of pathogenic mtDNA mutations. The entire mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23799027
DOI: 10.1371/journal.pone.0065578
PMCID: PMC3683038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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