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Article

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma.

Oncotarget - 1 Jul 2012

Uzawa Katsuhiro, Baba Takao, Uchida Fumihiko, Yamatoji Masanobu, Kasamatsu Atsushi, Sakamoto Yosuke, Ogawara Katsunori, Shiiba Masashi, Bukawa Hiroki, Tanzawa Hideki

Abstract excerpt

While circulating tumor-derived molecules have been identified in a variety of malignant tumors, it is sometimes difficult to detect the molecular targets due to the lower serum concentration. We report that evaluation of circulating tumor-derived mitochondrial DNA (mtDNA) seems to have novel efficiency for detecting tumoral micrometastasis. In murine xenografting human oral cancer cells, human mtDNAs could be...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22832574
DOI: 10.18632/oncotarget.523
PMCID: PMC3443250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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