Article
Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2016
Chattopadhyay Esita, De Sarkar Navonil, Singh Richa, Ray Anindita, Roy Roshni, Paul Ranjan Rashmi, Pal Mousumi, Ghose Sandip, Ghosh Subhrendu, Kabiraj Debajyoti, Banerjee Raja, Roy Bidyut
Abstract excerpt
Several studies reported that mtDNA mutations may play important roles in carcinogenesis although the mechanism is not clear yet. Most of the studies compared mtDNA sequences in a tumor with those in normal tissues from different individuals ignoring inter-individual variations. In this study, 271 SNPs, 7 novel SNPs (or SNVs), and 15 somatic mutations were detected in mtDNA of 8 oral cancer tissues with respect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.