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Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients

5 Feb 2014

Abstract excerpt

OBJECTIVES: Alterations in mitochondrial DNA (mtDNA) copy number have been widely reported in various human cancers, and been considered to be an important hallmark of cancers. However, little is known about the value of copy number variations of mtDNA in the prognostic evaluation of laryngeal cancer. DESIGN AND METHODS: Using real-time quantitative PCR method, we investigated mtDNA copy number in a cohort of...

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PMID: 24499477
DOI: 10.1186/1746-1596-9-28

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