Mitochondrial DNA alterations correlate with the pathological status and the immunological ER, PR, HER-2/neu, p53 and Ki-67 expression in breast invasive ductal carcinoma.

doi:10.3892/or.2015.3887

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Mitochondrial DNA alterations correlate with the pathological status and the immunological ER, PR, HER-2/neu, p53 and Ki-67 expression in breast invasive ductal carcinoma.

Oncology reports - 1 Jun 2015

Lin Chen-Sung, Chang Shi-Chuan, Ou Liang-Hung, Chen Chien-Ming, Hsieh Sophie Swen-Wan, Chung Yu-Ping, King Kuang-Liang, Lin Shoei-Loong, Wei Yau-Huei

Abstract excerpt

We analyzed the changes in mitochondrial DNA (mtDNA) copy numbers and the shifting of mtDNA D310 sequence variations (D310 mutation) with their relationships to pathological status and the expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2/neu), tumor-suppressor protein p53 and cellular proliferation protein Ki-67 in breast invasive ductal...

Topics

Aged
Breast Neoplasms
Carcinoma, Ductal
Cell Proliferation
DNA Copy Number Variations
DNA, Mitochondrial
Estrogen Receptor alpha
Female
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Ki-67 Antigen

Middle Aged

Mutation

Prognosis

Receptor, ErbB-2

Receptors, Progesterone

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 25845386
DOI: 10.3892/or.2015.3887

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