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Article

Analysis of Smoothened Phosphorylation and Activation in Cultured Cells and Wing Discs of Drosophila.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Jiang Kai, Jia Jianhang

Abstract excerpt

Smoothened (Smo) is essential for transduction of the Hedgehog (Hh) signal in both insects and vertebrates. Binding of Hh to Ptc-Ihog relieves the Patched (Ptc)-mediated inhibition of Smo, which allows Smo to activate the cubitus interruptus (Ci)/Gli family of zinc finger transcription factors and thereby induce the expression of Hh target genes, such as decapentaplegic (dpp), ptc, and engrailed (en). The...

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PMID: 26179038
DOI: 10.1007/978-1-4939-2772-2_5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of Smoothened Phosphorylation and Activation in Cultured Cells and Wing Discs of Drosophila.PMID 26179038Read ↗

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Hedgehog regulates smoothened activity by inducing a conformational switch.Semantic proximity Read ↗

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.Semantic proximity Read ↗

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Semantic proximity Read ↗

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