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Article

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

Development (Cambridge, England) - 1 Dec 1998

Chen Y, Struhl G

Abstract excerpt

During Drosophila development, cells belonging to the posterior compartment of each segment organize growth and patterning by secreting Hedgehog (Hh), a protein which induces a thin strip of adjacent cells in the anterior compartment to express the morphogens Decapentaplegic (Dpp) and Wingless (Wg). Hedgehog is bound and transduced by a receptor complex that includes Smoothened (Smo), a member of the Frizzled...

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Identifiers

PMID: 9811578
DOI: 10.1242/dev.125.24.4943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.PMID 9811578Read ↗

Dual roles for patched in sequestering and transducing Hedgehog.Semantic proximity Read ↗

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.Semantic proximity Read ↗

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.Semantic proximity Read ↗

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.Semantic proximity Read ↗

Characterization of two patched receptors for the vertebrate hedgehog protein familySemantic proximity Read ↗

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.Semantic proximity Read ↗

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.Semantic proximity Read ↗

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 SecretionSemantic proximity Read ↗

Genetic and biochemical definition of the Hedgehog receptor.Semantic proximity Read ↗

Altered neural cell fates and medulloblastoma in mouse patched mutants.Semantic proximity Read ↗

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