Article
In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.
Development (Cambridge, England) - 1 Dec 1998
Chen Y, Struhl G
Abstract excerpt
During Drosophila development, cells belonging to the posterior compartment of each segment organize growth and patterning by secreting Hedgehog (Hh), a protein which induces a thin strip of adjacent cells in the anterior compartment to express the morphogens Decapentaplegic (Dpp) and Wingless (Wg). Hedgehog is bound and transduced by a receptor complex that includes Smoothened (Smo), a member of the Frizzled...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- Drosophila
- Drosophila Proteins
- Genes, Reporter
- Genotype
- Hedgehog Proteins
- Insect Proteins
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Protein Binding
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Sequence Analysis, DNA
- Signal Transduction
- Smoothened Receptor