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Article

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

11 Jul 2006

Abstract excerpt

The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from inhibition. The mechanism behind Ptch1-dependent Smo inhibition remains unresolved. We now show that by mixing Ptch1-transfected and Ptch1 small interfering RNA-transfected cells with Gli reporter cells, Ptch1 is...

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PMID: 16895439
DOI: 10.1371/journal.pbio.0040232

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Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 SecretionPMID 16895439Read ↗

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Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Semantic proximity Read ↗

Regulation of the oncoprotein Smoothened by small molecules.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

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