Article
The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.
Current biology : CB - 17 Apr 2001
Martín V, Carrillo G, Torroja C, Guerrero I
Abstract excerpt
The Hedgehog (Hh) family of signaling molecules function as organizers in many morphogenetic processes. Hh signaling requires cholesterol in both signal-generating and -receiving cells, and it requires the tumor suppressor Patched (Ptc) in receiving cells in which it plays a negative role. Ptc both blocks the Hh pathway and limits the spread of Hh. Sequence analysis suggests that it has 12 transmembrane segments,...
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