Article
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Molecular cell - 6 Apr 2017
Xiao Xu, Tang Jing-Jie, Peng Chao, Wang Yan, Fu Lin, Qiu Zhi-Ping, Xiong Yue, Yang Lian-Fang, Cui Hai-Wei, He Xiao-Long, Yin Lei, Qi Wei, Wong Catherine C L, Zhao Yun, Li Bo-Liang, Qiu Wen-Wei, Song Bao-Liang
Abstract excerpt
Hedgehog (Hh) has been known as the only cholesterol-modified morphogen playing pivotal roles in development and tumorigenesis. A major unsolved question is how Hh signaling regulates the activity of Smoothened (SMO). Here, we performed an unbiased biochemical screen and identified that SMO was covalently modified by cholesterol on the Asp95 (D95) residue through an ester bond. This modification was inhibited by...
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