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Article

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

Nature - 23 Dec 2004

Jia Jianhang, Tong Chao, Wang Bing, Luo Liping, Jiang Jin

Abstract excerpt

The Hedgehog (Hh) family of secreted proteins governs cell growth and patterning in animal development. The Hh signal is transduced by the seven-transmembrane protein Smoothened (Smo); however, the mechanism by which Smo is regulated remains largely unknown. Here we show that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell-surface accumulation and activity in response to Hh. Blocking PKA or CKI...

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Identifiers

PMID: 15616566
DOI: 10.1038/nature03179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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