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Article

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.

Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004

Zhang Chi, Williams Elizabeth H, Guo Yurong, Lum Lawrence, Beachy Philip A

Abstract excerpt

The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in Drosophila have correlated pathway activation with Smo accumulation and increased phosphorylation. Using immunopurification and mass spectrometry, we identify here 26 serine/threonine residues within the Smo...

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Identifiers

PMID: 15598741
DOI: 10.1073/pnas.0408093101
PMCID: PMC535705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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