Article
Role of lipid metabolism in smoothened derepression in hedgehog signaling.
Developmental cell - 20 Jul 2010
Yavari Amir, Nagaraj Raghavendra, Owusu-Ansah Edward, Folick Andrew, Ngo Kathy, Hillman Tyler, Call Gerald, Rohatgi Rajat, Scott Matthew P, Banerjee Utpal
Abstract excerpt
The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generation of PI4P, exhibits hh loss-of-function phenotypes, whereas loss of Sac1 phosphatase, which is...
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