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Article

Hedgehog regulates smoothened activity by inducing a conformational switch.

Nature - 8 Nov 2007

Zhao Yun, Tong Chao, Jiang Jin

Abstract excerpt

Hedgehog (HH) morphogen is essential for metazoan development. The seven-transmembrane protein smoothened (SMO) transduces the HH signal across the plasma membrane, but how SMO is activated remains poorly understood. In Drosophila melanogaster, HH induces phosphorylation at multiple Ser/Thr residues in the SMO carboxy-terminal cytoplasmic tail, leading to its cell surface accumulation and activation. Here we...

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Source

Identifiers

PMID: 17960137
DOI: 10.1038/nature06225

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hedgehog regulates smoothened activity by inducing a conformational switch.PMID 17960137Read ↗

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