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Article

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.

Mechanisms of development - 1 Jun 2004

Nakano Y, Nystedt S, Shivdasani A A, Strutt H, Thomas C, Ingham P W

Abstract excerpt

The Hedgehog signalling pathway is deployed repeatedly during normal animal development and its inappropriate activity is associated with various tumours in human. The serpentine protein Smoothened (Smo) is essential for cells to respond to the Hedeghog (Hh) signal; oncogenic forms of Smo have been isolated from human basal cell carcinomas. Despite similarities with ligand binding G-protein coupled receptors, the...

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Identifiers

PMID: 15172682
DOI: 10.1016/j.mod.2004.04.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.PMID 15172682Read ↗

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.Semantic proximity Read ↗

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.Semantic proximity Read ↗

Analysis of Smoothened Phosphorylation and Activation in Cultured Cells and Wing Discs of Drosophila.Semantic proximity Read ↗

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.Semantic proximity Read ↗

Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.Semantic proximity Read ↗

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.Semantic proximity Read ↗

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Semantic proximity Read ↗

Hedgehog regulates smoothened activity by inducing a conformational switch.Semantic proximity Read ↗

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.Semantic proximity Read ↗

Bi-allelic Variations of SMO in Humans Cause a Broad Spectrum of Developmental Anomalies Due to Abnormal Hedgehog Signaling.Semantic proximity Read ↗

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