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Article

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.

PLoS biology - 1 Jun 2016

Li Shuangxi, Li Shuang, Han Yuhong, Tong Chao, Wang Bing, Chen Yongbin, Jiang Jin

Abstract excerpt

Hedgehog (Hh) signaling controls embryonic development and adult tissue homeostasis through the G protein coupled receptor (GPCR)-family protein Smoothened (Smo). Upon stimulation, Smo accumulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be essential for its activation and function, but the underlying mechanisms remain poorly understood. Here we show that Hh...

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Identifiers

PMID: 27280464
DOI: 10.1371/journal.pbio.1002481
PMCID: PMC4900676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.PMID 27280464Read ↗

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

Analysis of Smoothened Phosphorylation and Activation in Cultured Cells and Wing Discs of Drosophila.Semantic proximity Read ↗

Hedgehog regulates smoothened activity by inducing a conformational switch.Semantic proximity Read ↗

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.Semantic proximity Read ↗

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The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.Semantic proximity Read ↗

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.Semantic proximity Read ↗

Vertebrate Smoothened functions at the primary cilium.Semantic proximity Read ↗

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.Semantic proximity Read ↗

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.Semantic proximity Read ↗

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