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Article

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015

Holmes J Bradley, Akman Gokhan, Wood Stuart R, Sakhuja Kiran, Cerritelli Susana M, Moss Chloe, Bowmaker Mark R, Jacobs Howard T, Crouch Robert J, Holt Ian J

Abstract excerpt

Encoding ribonuclease H1 (RNase H1) degrades RNA hybridized to DNA, and its function is essential for mitochondrial DNA maintenance in the developing mouse. Here we define the role of RNase H1 in mitochondrial DNA replication. Analysis of replicating mitochondrial DNA in embryonic fibroblasts lacking RNase H1 reveals retention of three primers in the major noncoding region (NCR) and one at the prominent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26162680
DOI: 10.1073/pnas.1503653112
PMCID: PMC4522766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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