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Article

An overview of mammalian mitochondrial DNA replication mechanisms.

Journal of biochemistry - 1 Sept 2018

Yasukawa Takehiro, Kang Dongchon

Abstract excerpt

While the majority of DNA is enclosed within the nucleus, the mitochondria also contain their own, separate DNA, the mitochondrial DNA (mtDNA). Mutations in mtDNA are associated with various human diseases, demonstrating the importance of mtDNA. Intensive studies over the last 18 years have demonstrated the presence of two distinct classes of mtDNA replication intermediates in mammals. One involves leading-strand...

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Identifiers

PMID: 29931097
DOI: 10.1093/jb/mvy058
PMCID: PMC6094444

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