Article
Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ.
DNA repair - 1 Feb 2013
Clausen Anders R, Zhang Sufang, Burgers Peter M, Lee Marietta Y, Kunkel Thomas A
Abstract excerpt
In both budding and fission yeast, a large number of ribonucleotides are incorporated into DNA during replication by the major replicative polymerases (Pols α, δ and ɛ). They are subsequently removed by RNase H2-dependent repair, which if defective leads to replication stress and genome instability. To extend these studies to humans, where an RNase H2 defect results in an autoimmune disease, here we compare the...
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