Article
Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016
Akman Gokhan, Desai Radha, Bailey Laura J, Yasukawa Takehiro, Dalla Rosa Ilaria, Durigon Romina, Holmes J Bradley, Moss Chloe F, Mennuni Mara, Houlden Henry, Crouch Robert J, Hanna Michael G, Pitceathly Robert D S, Spinazzola Antonella, Holt Ian J
Abstract excerpt
The genetic information in mammalian mitochondrial DNA is densely packed; there are no introns and only one sizeable noncoding, or control, region containing key cis-elements for its replication and expression. Many molecules of mitochondrial DNA bear a third strand of DNA, known as "7S DNA," which forms a displacement (D-) loop in the control region. Here we show that many other molecules contain RNA as a third...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.