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Article

Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice.

Molecular cell - 1 Mar 2003

Cerritelli Susana M, Frolova Ella G, Feng Chiguang, Grinberg Alexander, Love Paul E, Crouch Robert J

Abstract excerpt

Although ribonucleases H (RNases H) have long been implicated in DNA metabolism, they are not required for viability in prokaryotes or unicellular eukaryotes. We generated Rnaseh1(-/-) mice to investigate the role of RNase H1 in mammals and observed developmental arrest at E8.5 in null embryos. A...

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PMID: 12667461
DOI: 10.1016/s1097-2765(03)00088-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12667461-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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