Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNase H2 roles in genome integrity revealed by unlinking its activities.

Nucleic acids research - 1 Mar 2013

Chon Hyongi, Sparks Justin L, Rychlik Monika, Nowotny Marcin, Burgers Peter M, Crouch Robert J, Cerritelli Susana M

Abstract excerpt

Ribonuclease H2 (RNase H2) protects genome integrity by its dual roles of resolving transcription-related R-loops and ribonucleotides incorporated in DNA during replication. To unlink these two functions, we generated a Saccharomyces cerevisiae RNase H2 mutant that can resolve R-loops but cannot cleave single ribonucleotides in DNA. This mutant definitively correlates the 2-5 bp deletions observed in rnh201Δ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to Hydrogen Bonding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Ribonuclease H

Share to Ribonucleases

Share to Structural Homology, Protein

Share to Thermotoga maritima

Source

Open in PubMed Open full text

Identifiers

PMID: 23355612
DOI: 10.1093/nar/gkt027
PMCID: PMC3597693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNase H2 roles in genome integrity revealed by unlinking its activities.PMID 23355612Read ↗

Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammationSemantic proximity Read ↗

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integritySemantic proximity Read ↗

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescueSemantic proximity Read ↗

A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability.Semantic proximity Read ↗

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read ↗

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex.Semantic proximity Read ↗

Ribonuclease H2 in health and diseaseSemantic proximity Read ↗

Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phaseSemantic proximity Read ↗

The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.Semantic proximity Read ↗

Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity.Semantic proximity Read ↗

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.