Article

DCLRE1B/hSNM1B (Apollo) is not acutely required for human pluripotent stem cell survival

2023-07-30

Abstract excerpt

Telomeric DNA ends in a 3’ single stranded overhang that is implicated in the protective function of telomeres ensuring genomic stability in mammals. Telomere overhang formation relies on the coordinated interplay between DNA synthesis and exonuclease activity. DCLRE1B/hSNM1B/Apollo generates an initial resection at the newly synthesized, blunt-ended leading strand telomere. This resection is thought to be require...

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Literature Corpus work: a0ebc3b0-d84d-5d31-8ab3-4c06cda4aac7
DOI: 10.1101/2023.07.29.551071

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