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A structure-selective endonuclease drives uniparental mitochondrial DNA inheritance

2026-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Maternal inheritance of mitochondrial DNA (mtDNA) is a near-universal feature of eukaryotes 1 , yet the mechanisms that ensure this by preventing paternal mtDNA inheritance have remained unclear. In both Drosophila and humans, mtDNA is actively eliminated from sperm during spermatogenesis, producing mature sperm whose mitochondria lack their genomes 2–5 . Here we identify Hotaru, a previously...

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Literature Corpus work
979add5d-4ec2-5cc3-82e7-99c5430758fd
DOI
10.64898/2026.03.19.713005
Open publication

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A structure-selective endonuclease drives uniparental mitochondrial DNA inheritanceDOI 10.64898/2026.03.19.713005
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