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Article

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015

Dettmer Ulf, Newman Andrew J, von Saucken Victoria E, Bartels Tim, Selkoe Dennis

Abstract excerpt

α-Synuclein (αS) is a highly abundant neuronal protein that aggregates into β-sheet-rich inclusions in Parkinson's disease (PD). αS was long thought to occur as a natively unfolded monomer, but recent work suggests it also occurs normally in α-helix-rich tetramers and related multimers. To elucidate the fundamental relationship between αS multimers and monomers in living neurons, we performed systematic...

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Identifiers

PMID: 26153422
DOI: 10.1073/pnas.1505953112
PMCID: PMC4534262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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