Article
Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids.
Neurobiology of disease - 1 Oct 2014
Zarbiv Yonaton, Simhi-Haham Dganit, Israeli Eitan, Elhadi Suaad Abed, Grigoletto Jessica, Sharon Ronit
Abstract excerpt
While α-Synuclein (α-Syn) is mainly detected as a cytosolic protein, a portion of it is recovered bound to membranes. It is suggested that binding to membrane phospholipids controls α-Syn structure, physiology and pathogenesis. We aimed at investigating the role, of the positive charged lysine residues at the KTKEGV repeat motif, in mediating α-Syn associations with membrane phospholipids and in α-Syn...
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