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Article

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

PloS one - 1 Jan 2015

Deng Xinzhu, Michaelson David, Tchieu Jason, Cheng Jin, Rothenstein Diana, Feldman Regina, Lee Sang-gyu, Fuller John, Haimovitz-Friedman Adriana, Studer Lorenz, Powell Simon, Fuks Zvi, Hubbard E Jane Albert, Kolesnick Richard

Abstract excerpt

Mammalian NOTCH1-4 receptors are all associated with human malignancy, although exact roles remain enigmatic. Here we employ glp-1(ar202), a temperature-sensitive gain-of-function C. elegans NOTCH mutant, to delineate NOTCH-driven tumor responses to radiotherapy. At ≤20°C, glp-1(ar202) is wild-type, whereas at 25°C it forms a germline stem cell⁄progenitor cell tumor reminiscent of human cancer. We identify a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26120834
DOI: 10.1371/journal.pone.0127862
PMCID: PMC4485896

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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