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Article

Inheritance of paternal DNA damage by histone-mediated repair restriction.

Nature - 1 Jan 2023

Wang Siyao, Meyer David H, Schumacher Björn

Abstract excerpt

How paternal exposure to ionizing radiation affects genetic inheritance and disease risk in the offspring has been a long-standing question in radiation biology. In humans, nearly 80% of transmitted mutations arise in the paternal germline1, but the transgenerational effects of ionizing radiation exposure has remained controversial and the mechanisms are unknown. Here we show that in sex-separated Caenorhabditis...

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Identifiers

PMID: 36544019
DOI: 10.1038/s41586-022-05544-w
PMCID: PMC9834056

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