Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RTEL1 maintains genomic stability by suppressing homologous recombination.

Cell - 17 Oct 2008

Barber Louise J, Youds Jillian L, Ward Jordan D, McIlwraith Michael J, O'Neil Nigel J, Petalcorin Mark I R, Martin Julie S, Collis Spencer J, Cantor Sharon B, Auclair Melissa, Tissenbaum Heidi, West Stephen C, Rose Ann M, Boulton Simon J

Abstract excerpt

Homologous recombination (HR) is an important conserved process for DNA repair and ensures maintenance of genome integrity. Inappropriate HR causes gross chromosomal rearrangements and tumorigenesis in mammals. In yeast, the Srs2 helicase eliminates inappropriate recombination events, but the functional equivalent of Srs2 in higher eukaryotes has been elusive. Here, we identify C. elegans RTEL-1 as a functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to DNA Repair

Share to Genomic Instability

Share to Recombination, Genetic

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18957201
DOI: 10.1016/j.cell.2008.08.016
PMCID: PMC3726190

Genes

RTEL1
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RTEL1 maintains genomic stability by suppressing homologous recombination.PMID 18957201Read ↗

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.Semantic proximity Read ↗

[RTEL1 (regulator of telomere elongation helicase 1), a DNA helicase essential for genome stability].Semantic proximity Read ↗

Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome.Semantic proximity Read ↗

Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.Semantic proximity Read ↗

RTEL1: functions of a disease-associated helicase.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects.Semantic proximity Read ↗

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop UnwindingSemantic proximity Read ↗

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicasesSemantic proximity Read ↗

RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.Semantic proximity Read ↗

The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.Semantic proximity Read ↗

trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.