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Article

A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 3 Dec 2020

Dalfó Diana, Ding Yanhui, Liang Qifei, Fong Alex, Cipriani Patricia Giselle, Piano Fabio, Zheng Jialin C, Qin Zhao, Hubbard E Jane Albert

Abstract excerpt

Stem cells are tightly controlled in vivo Both the balance between self-renewal and differentiation and the rate of proliferation are often regulated by multiple factors. The Caenorhabditis elegans hermaphrodite germ line provides a simple and accessible system for studying stem cells in vivo In this system, GLP-1/Notch activity prevents the differentiation of distal germ cells in response to ligand production...

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Identifiers

PMID: 33077477
DOI: 10.1534/g3.120.401632
PMCID: PMC7718737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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