Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.

doi:10.1093/nar/gkx660

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Article

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.

Nucleic acids research - 19 Sept 2017

Wilson David M, Rieckher Matthias, Williams Ashley B, Schumacher Björn

Abstract excerpt

DNA interstrand crosslinks (ICLs) are generated by endogenous sources and chemotherapeutics, and pose a threat to genome stability and cell survival. Using Caenorhabditis elegans mutants, we identify DNA repair factors that protect against the genotoxicity of ICLs generated by trioxsalen/ultraviolet A (TMP/UVA) during development and aging. Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and...