Article
A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006
Weidhaas J B, Eisenmann D M, Holub J M, Nallur S V
Abstract excerpt
We have developed a tissue model of radiation-induced reproductive cell death in the nematode Caenorhabditis elegans. Reproductive cell death is the primary mode of death in tissue multipotential precursor cells, or "clonogens," the targets of cytotoxic therapy, whose elimination results in normal tissue damage as well as solid-tumor eradication. Through extensive morphologic and genetic analysis, we have...
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