Article

Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma

2024-11-12

Abstract excerpt

<h4>Summary</h4> Specific and biologically informed treatments for medulloblastoma, especially the highly lethal TP53 mutant SHH subgroup, remain elusive, where radiotherapy is the primary treatment option. Applying genome-wide CRISPR-Cas9 screening in combination with lethal doses of radiotherapy, we identified the main driver of radiation resistance in SHH medulloblastoma is loss of p53. A negative selection C...

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Literature Corpus work: bc4aee5f-fc87-573b-a18d-2a204a250fca
DOI: 10.1101/2024.11.11.622104

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