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Article

Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation.

PloS one - 1 Jan 2021

Meier Bettina, Volkova Nadezda V, Hong Ye, Bertolini Simone, González-Huici Víctor, Petrova Tsvetana, Boulton Simon, Campbell Peter J, Gerstung Moritz, Gartner Anton

Abstract excerpt

Maintaining genome integrity is particularly important in germ cells to ensure faithful transmission of genetic information across generations. Here we systematically describe germ cell mutagenesis in wild-type and 61 DNA repair mutants cultivated over multiple generations. ~44% of the DNA repair mutants analysed showed a >2-fold increased mutagenesis with a broad spectrum of mutational outcomes. Nucleotide...

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PMID: 33905417
DOI: 10.1371/journal.pone.0250291
PMCID: PMC8078821

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