Article
C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation.
PloS one - 1 Jan 2021
Meier Bettina, Volkova Nadezda V, Wang Bin, González-Huici Víctor, Bertolini Simone, Campbell Peter J, Gerstung Moritz, Gartner Anton
Abstract excerpt
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution of DNA repair pathways for mending IR-induced lesions. Here, using C. elegans as a model system and using primary sequencing data from our recent high-level overview of the mutagenic...
Topics
- Animals
- Caenorhabditis elegans
- Cisplatin
- DNA Repair
- Genome, Helminth
- Humans
- Mutation
- Neoplasms
- Polymorphism, Single Nucleotide
- Radiation, Ionizing
- Ultraviolet Rays