Article

Transgenerational inheritance of paternal DNA damage by linker histone H1-mediated DNA repair restriction

2022-05-06

Abstract excerpt

<title>Abstract</title> <p>How paternal exposure to ionizing radiation (IR) affects genetic inheritance and disease risk in the offspring has been one of the most long-standing questions in radiation biology. While in humans, 80% of transmitted mutations arise in the paternal germline, the transgenerational effects of ionizing radiation (IR)-exposure has remained controversial and the mechanisms elusive. Here, we...

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Literature Corpus work: 141076ba-dcd1-5b47-9d2d-a346d7c1726c
DOI: 10.21203/rs.3.rs-1602124/v1

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