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Article

Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2015

Kim Kwangwoo, Jiang Xia, Cui Jing, Lu Bing, Costenbader Karen H, Sparks Jeffrey A, Bang So-Young, Lee Hye-Soon, Okada Yukinori, Raychaudhuri Soumya, Alfredsson Lars, Bae Sang-Cheol, Klareskog Lars, Karlson Elizabeth W

Abstract excerpt

OBJECTIVE: To define the interaction between cigarette smoking and HLA polymorphisms in seropositive rheumatoid arthritis (RA), in the context of a recently identified amino acid-based HLA model for RA susceptibility. METHODS: We imputed Immunochip data on HLA amino acids and classical alleles from 3 case-control studies (the Swedish Epidemiological Investigation of Rheumatoid Arthritis [EIRA] study [1,654 cases...

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Topics

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Share to Amino Acids
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to HLA-B Antigens

Share to HLA-DP beta-Chains

Share to HLA-DRB1 Chains

Share to Models, Genetic

Share to Smoking

Source

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Identifiers

PMID: 26098791
DOI: 10.1002/art.39228
PMCID: PMC4581918

Genes

NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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