Article
DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.
Arthritis research & therapy - 29 Mar 2017
Meng Weida, Zhu Zaihua, Jiang Xia, Too Chun Lai, Uebe Steffen, Jagodic Maja, Kockum Ingrid, Murad Shahnaz, Ferrucci Luigi, Alfredsson Lars, Zou Hejian, Klareskog Lars, Feinberg Andrew P, Ekström Tomas J, Padyukov Leonid, Liu Yun
Abstract excerpt
BACKGROUND: Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). However, the underlying mechanism is not fully understood. This study was undertaken to evaluate whether DNA methylation can mediate the interaction between genotype and smoking in the development of anti-citrullinated peptide antibody (ACPA)-positive RA....
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